Endpoint Security Now Available in WatchGuard Cloud. The breakthrough, published in Science, adds new evidence that it will eventually be possible to help patients recover muscle lost in heart attacks and gives another boon to anti-aging researchers who want to one day apply these rejuvenation techniques across much of the body. Perhaps anticipating a walkover with an FDA approval in hand, Biogen has instead faced a wall of pushback over its controversial Alzheimer’s med Aduhelm. With payers and clinics largely staying away, Biogen’s drug is posting some troubling safety signals that could derail the launch even further. The web feature with profiles on each company is available to Endpoints readers with a premium subscription at ENDPTS.COM. The SaaS Awards is a sister program to the Cloud Awards, which was founded in 2011. Amber Tong ... ENDPOINTS NEWS by John Carroll & team — all the news at 11:30am ET. This year marks our first foray into the world of UC Channel Awards, and we couldn’t be more excited. Endpoints News Latest Breaking News, Pictures, Videos, and Special Reports from The Economic Times. "We're celebrating science and entrepreneurship and telling stories about creating the fastest companies in biopharma, from the ground up, with all the risks and potential rewards. This book and practice will help readers positively impact every area of their physical and mental health through mindfulness, from productivity and focus, to stress and anxiety relief, sleep, weight-loss, personal relationships...and the ... Please note the magic link is But microbiome players are posting promising signs that replenishing healthy gut bacteria, rather than simply killing them off alongside the bad ones, can make a difference. Founded in 2016 by editor John Carroll and publisher Arsalan Arif , … Both drugs are designed to address antibiotic-resistant infections, with Vedanta’s VE303 aimed at C. difficile infections and Locus Biosciences’ LBP-EC01 intended to treat recurrent UTIs caused by E. coli. And the unlimited-seat Enterprise program gives companies of all sizes access to Endpoints for one flat price. «This year more than ever before, we see biotechs raising unprecedented amounts of money to pursue dramatic new gains in therapeutics,» says John Carroll, the founding editor of Endpoints. Life sciences marketers work with long sales cycles and products that require market education — which make webinars one of the most essential tools in the biopharma demand generation toolbox. Endpoints News names the 11 most promising biotech startups of 2021, Download the Globe app to my phone or tablet, https://www.prnewswire.com/news-releases/endpoints-news-names-the-11-most-promising-biotech-startups-of-2021-301382188.html, Longtime Joplin manufacturer ready to hire as expansion wraps up, Employers chasing shrinking pool of workers in Joplin, Neosho School District defends policy; group mobilizes to press for change, D&D Sexton celebrates 40 years in Carthage, Former PSU basketball standout Pate passes away, Lions stun Bronchos, earn first win of MIAA football season, Joplin musician releases first solo single. Breaking News. Duration: 1 hour. Subscriptions. Announced earlier this month, Versa SASE earned the Highly Commended distinction in the program’s Best Emerging Technology awards category. "Every year, Endpoints 11 represents the best of biotech — and the best of Endpoints News," says Endpoints founding publisher Arsalan Arif. Lucy Parsons. Nevertheless, Overtreated ultimately conveys a message of hope by reframing the debate over health care reform. It offers a way to control costs and cover the uninsured, while simultaneously improving the quality of American medicine. The 2019 awards are: Migraine Clinical Outcome Assessment System (MiCOAS) – This project will develop and standardize a core set of endpoints and … M&A Insights 2021 is now on-demand – register for FREE now Arrangements under the direction of Clark Funeral Home, Neosho. Found inside – Page 306PCOR Grant Awards. Retrieved August 29, 2015 from http://www.ahrq.gov/news/ newsroom/press-releases/2015/pcorawards.html. Agency for Healthcare. The winners of UC Awards 2021 have been decided – Watch it Now. . Found inside – Page 7SCIENCE IN THE NEWS 1 . ... old tribal records has identiUnited States under its Russell and Burch Awards fied a chromosomal site associated with the connec ... Your seat is reserved! Founded in 2016 by editor John Carroll and publisher Arsalan Arif, Endpoints has become the way drug development executives stay informed. ColorTokens Inc., a leading innovator in zero trust-based cybersecurity solutions, today announced it had taken home four wins at the 17th Annual 2021 Get weekly news delivered directly to your inbox UCaaS Market to Hit $70bn in 2028. Improving endpoint selection in Alzheimer’s disease trials. Found inside – Page 1REPRODUCTIVE EFFECTS endpoints emphasized by OPTS ' Moore . EPA AWARDS TO EMPLOYEES go to OTS , OPP , hazardous waste workers . Page 30 Page 16 Page 14 TSCA ... Get weekly news delivered directly to your inbox UCaaS Market to Hit $70bn in 2028. San Jose, Calif., June 22, 2021. News provided by. About Endpoints. If you're already an Endpoints subscriber, enter your email below for a We’re here to celebrate you. UC Today Breaking News Channel News. Selected by Endpoints News founder and editor John Carroll, the Endpoints 11 recognizes biotech companies that are poised to develop new and impactful medicines: an outstanding team, a transformative approach/platform, and substantial capital. In the age of remote working, coupled with a mobile-first approach to application development, an organization’s network perimeter consists of … Found insideMark Vanhoenacker, a 747 pilot who left academia and a career in the business world to pursue his childhood dream of flight, asks us to reimagine what we—both as pilots and as passengers—are actually doing when we enter the world ... Sign up now to get our FREE breaking news coverage delivered right to your inbox. There is no charge to attend Endpoints 11, and registration is open to all biopharma professionals at eleven21.endpts.com. C. diff is a notoriously tough infection to battle, with an estimated 20% of all US patients — and there are up to a quarter million of them each year — estimated to suffer from recurrence. News & Articles. magic link that lets you log in quickly without using a password. This book extends what we know about the development of civil rights and the role of the NAACP in American politics. Explores business development in the Black power era and the centrality of economic goals to the larger black freedom movement. Within them are CRISPR-Cas3 constructs that should degrade the DNA of the target bacterial cell, killing off any E. coli that might have escaped the bacteriophages. Found inside – Page 293Available at: https://www. prnewswire.com/news-releases/nih-awards-majorgrant-in-pulmonary-fibrosis- ... Home monitoring improves endpoint efficiency in ... Thanks to our sponsors Catalent and Egnyte for making this event possible.". Winds NE at 5 to 10 mph.. Clear skies. The In-Wall Switch is a flush-mount version of their popular desktop device which expands a single PoE network connection into one or two PoE network ports.. Humane interventions are actions designed to prevent or relieve unnecessary pain or distress including, but not limited to, the following: Increasing the frequency of animal observations. Found inside – Page 270... particularly on behavioral endpoints. 96. NIH, “NIEHS Awards Recovery Act Funds to Address Bisphenol A Research Gaps,” press release, October 28, 2009. The 2021 Endpoints 11 is sponsored by Catalent. Found insideTimely and accessibly written, this book provides a unique, comprehensive introduction to psychogastroenterology, offering a step-by-step guide to evidence-based psychological treatment protocols. Endpoints News brings together the biopharma world’s top authorities virtually to discuss the biggest issues confronting the industry today. M&A Insights 2021 is now on-demand – register for FREE now Visit our new dedicated site CX TODAY. “Infections associated with long-term antibiotic use are a growing concern and are often costly to treat which makes developing novel drugs and technologies for prevention and treatment all the more urgent for U.S. health security.”. The 2021 Endpoints 11 is sponsored by Catalent. Latest News Avance Clinical Awarded Frost & Sullivan 2021 Asia-Pacific CRO Best Practices Award for Customer Value Leadership August 10, 2021 Avance Clinical Congratulates Client Tetherex Pharmaceuticals on Initiation of Dosing in a Phase 1 Clinical Study Using a Novel Single-Cycle Adenovirus Vaccine Strategy in Australia July 9, 2021 Read more >. Endpoints News names the 11 most promising biotech startups of 2021; Tunisia president takes new powers, says will reform system; Virtual Reality (VR) in Gaming Market to Reach USD 53.44 Billion by 2028; Ubisoft Entertainment SA Includes Splinter Cell and Assassin’s Creed in its Portfolio: Fortune Business Insights™ Advertising on the uncluttered Endpoints platform allows biopharma brands to stand out like nowhere else. Read daily by thousands of business and science leaders engaged in drug R&D around the world, your sponsorship will be presented to the C-suite and to legions of team players who make biopharma turn. August 18, 2021. A paid Insider subscription grants access to the entire content library and provides an ad-free experience. There's no cost for a Basic subscription, which provides readers access to daily news content and special features like the Endpoints 11. Of these there are 144 Phase 2 studies and 114 in Phase 3 and 4 studies. Protecting endpoints and preventing the spread of infected systems is a critical concern for organizations of all sizes. Amazon with IGEL ensure a streamlined, secure user-experience on your endpoints from anywhere, while reducing cost and increasing productivity. First Amendment: Congress shall make no law respecting an establishment of religion, or prohibiting the free exercise thereof; or abridging the freedom of speech, or of the press; or the right of the people peaceably to assemble, and to petition the Government for a redress of grievances. Found inside – Page 175This was very bad news. ... use of surrogate endpoints for rare disease (they have historically only been ... The biggest honor to me was having the award ... LAWRENCE, Kan., Dec. 10, 2020 /PRNewswire/ -- Live event today at 2 PM ET featuring this year's top 20 Women in Biopharma R&D honorees. Found insideTHE INSTITUTE FOR POLITICAL INNOVATION The authors will donate all royalties from the sale of this book to the Institute for Political Innovation. Bloomberg was unable to identify any bidders in the deal, but speculation has been running rampant that the surging value of Acceleron stock had to be the result of leaks around the auction of the company. Endpoints News is an independent news media company with 92,000 daily email subscribers. Winds SE at 5 to 10 mph. Registration is open at womeninbio20.endpts.com. Tanium, the provider of endpoint management and security built for the world’s most demanding IT environments, today announced that it won two awards On December 7, Endpoints News hosts Women in Biopharma: 20 of the top women leaders in biopharma R&D 2021. Endpoints Webinars. The SaaS Awards focuses on recognizing excellence and innovation in software solutions. Reported by a global team of journalists, Endpoints covers news as it happens and delivers an inimitable twice-daily email report to an engaged audience in the business of discovering, researching, marketing, and regulating biopharma drugs. You have permission to edit this article. Versa Networks, the leader in SASE, today announced that The Globee® Awards, organizers of the world’s premier business awards programs and business ranking lists, has named Versa as a winner in the 16th Annual IT World Awards® program. We’re thrilled to announce UC Partner Awards 2021 applications are now open! Low 58F. Imaging Endpoints (IE) is an imaging research and core laboratory that provides comprehensive imaging CRO (iCRO) services and technology solutions throughout the clinical trial process. Attendees will see exclusive footage of … A celebration of life will be at a later date. Endpoints is different because we treat our audience to a low-volume of high-quality advertising from qualified biopharma sponsors, partnered with our expert business team. That approach rewards both our clients with superior results while readers enjoy a premium reading experience. We invite you to schedule a conversation with our team. The SaaS Awards is a sister program to the Cloud Awards, which was founded in 2011. "Reporting these profiles is essential to Endpoints' mission to relentlessly cover the most important news in biopharma. Endpoints webinars are a turn-key solution — let us handle the audience generation, content, marketing, and tech. For John Updike, the writing of poetry was always a special joy, and this final collection is an eloquent and moving testament to the life of this extraordinary writer. CARB-X, the antibacterial research-focused public-private partnership that BARDA helped launch, backed the drug’s earlier development. I'd also like to thank our sponsors Catalent, IQVIA, and Koneksa Health for their support of our independent journalism," said Arsalan Arif, Endpoints News founder and publisher. Winners will be recognized today at a live event hosted by Endpoints editors Amber Tong and Nicole DeFeudis at 2 PM ET. I’m sorry I missed you. Endpoints News has transitioned its global events online and is committed to providing free access for attendees throughout the pandemic. Visit our new dedicated site CX TODAY. The 2021 Endpoints 11 winners are: Affinia Therapeutics. Cost: No Fee. Found insideThe book explores a wide variety of applications and examples, ranging from coincidences and paradoxes to Google PageRank and Markov chain Monte Carlo (MCMC). Additional "But money isn't enough. Sullivan joins Endpoints on the pharma manufacturing beat Josh Sullivan has joined Endpoints News as an associate editor on the pharmaceutical manufacturing beat. 8:00 - 9:00 LOCAL TIME. Now, the pharma partners are looking for a comeback in the first-line setting — and an interim look at Phase III data could give them the boost they need. When administered in combination with J&J’s Zytiga (a current standard of care), Lynparza achieved a statistically significant improvement in radiographic progression-free survival in a segment of men with advanced prostate cancer, compared to Zytiga alone, AstraZeneca and Merck announced on Friday. Teams hits 250m MAU, 80m Phone MAU. The 2021 Endpoints 11 is sponsored by Catalent. Found inside – Page 112The award term is from 1 September 1999 through 31 August 2002 . ... If teasible , other reproductive endpoints may be Merck Irving S. Sigal Memorial Award ... Most recently, he was a web producer at NBCUniversal Media. John Chiminski, Catalent's chairman and CEO, will present the awards live alongside Endpoints' John Carroll at a virtual event for subscribers at 3 pm ET on September 22. The Endpoints 11 is a list of companies with a shot at doing something big — and they’re taking on some big risks in a swing for the fences.”. Versa Networks, the leader in SASE, today announced that Versa SASE has been recognized as a winner in the SC Awards Europe 2021 awards program. Hartwig Gains Efficiency with Zero Trust Segmentation for Servers and Endpoints. Found inside – Page 9Young Farmer Family Award Routing Number Procedure Set The Federal Reserve ... number identify bona fide payments system endpoints , which for purposes of ... from 8 AM - 9 PM ET. Founded in 2016 by editor John Carroll and publisher Arsalan Arif, Endpoints has become the way drug development executives stay informed. In 2020 there was a total APP fraud loss of £479 million, according to UK.finance. 11:00 - 12:00 LOCAL TIME. Awards; Regulatory Code of Ethics. Found inside – Page 196... each other' without endpoints, and how this can lead to, for example, ... mentioned above watched a WBHS news announcement regarding the posting of ... A new vision of money as a communication technology that creates and sustains invisible--often exclusive--communities "In an engaging and timely work, brimming with fascinating anecdotes and historical and literary references, Lana Swartz ... Curtana Pharmaceuticals, an Austin, TX-based preclinical company, announced a partnership with the manufacturer Thursday to manufacture CT-179, its drug therapy for glioblastoma, medulloblastoma, and other brain tumors. Press contact: Shelly Whitfield, Operations Director ([email protected]), Cision Distribution 888-776-0942 Found insideQuillifer, with its engaging hero and his exploits with lovers, brawlers, warriors, and privateers, is a book that bursts with life. It’s the first volume in a new epic fantasy by bestselling and award-winning author Walter Jon Williams. San Jose, Calif., June 22, 2021. Graveside services were held Monday at Emmanuel Cemetery, Carthage. Its business model is centered around paid subscriptions, which grants access to the complete content library and more. In the complicated U.S. healthcare system, navigating a serious illness such as cancer or heart disease can be remarkably challenging for patients and caregivers. Looking for Contact Centre News? Not Found The requested URL /webpages/login.html was not found on this server. Seres, a pioneer in the field that packed its own selection of bacteria into a pill, failed its first try but has mounted a turnaround. The events were concerning enough to be categorized as suspected unexpected serious adverse reactions, or SUSARs. LAWRENCE, Kan., Sept. 22, 2021 /PRNewswire/ -- Endpoints News this morning unveiled the 2021 Endpoints 11 — the most promising biotech startup companies of the year. “Healthcare providers need tools at-the-ready to prevent or combat secondary bacterial infections, particularly those that impact a patient’s successful recovery following antibiotic usage in a public health emergency,” acting director Gary Disbrow said in a statement. This award designates Arrakis as one of the most promising private biotechnology companies with a “disruptive” approach to discovering and developing new medicines. Waltham, Mass., January 10, 2018 – Arrakis Therapeutics, a pioneering biopharmaceutical company, today announced that it has been named by Endpoints News as one of the “Endpoints 11” biotechnology companies of 2017. Days of frothy rumors about possible M&A discussions at Acceleron were capped late Friday with a Bloomberg report asserting that the biotech company is in advanced talks for an $11 billion buyout deal. Agilex Biolabs’ Director, Immunoassay, Kurt J. Developers can now build tools, apps, and services on the foundation of Spaces and enable users to experience the next phase of audio conversations on Twitter. It's great fun. 8 execs react to Zoom-Five9 acquisition. In the last one year, the company has delivered over 65 per cent return. The Howard Hughes Medical Institute — the nonprofit known for doling out generous investigator awards to biopharma’s rising stars — has selected … Bioscience & Technology Business CenterThe University of KansasLawrence, Kansas. Before joining, be sure to check system requirements to avoid any connection issues. Protein degradation: Looking back and moving forward. ET. It's time to go big or go home, So what happened with Novartis Gene Therapies? A year ago Australia was largely known predominantly for its early phase capabilities. Endpoints - Overview IPM+ an AI-enabled, multi US patented Endpoint management software that perform the functions of multiple endpoint products in one single product. The Phase III PEGASUS trial evaluated rilzabrutinib for the treatment of the rare autoimmune skin condition pemphigus. EARLY EDITION by Arsalan Arif — news and links at 7:15am ET. John D. Carroll is a biotech analyst and writer with decades of prize-winning experience in journalism. JOPLIN, MO - Paul Williamson Jr., 52, a machine operator, passed away Monday, September 20, 2021. CARTHAGE, MO - Clifford Eugene Johnson, 85, a retired truck driver, passed away Sunday, September 19, 2021. Waltham, Mass., January 10, 2018 – Arrakis Therapeutics, a pioneering biopharmaceutical company, today announced that it has been named by Endpoints News as one of the “Endpoints 11” biotechnology companies of 2017. ENDPOINTS … Endpoints News noemt de 11 meest veelbelovende biotech startups van 2021 Tunesische president krijgt nieuwe bevoegdheden, zegt systeem zal hervormen Virtual Reality (VR) in de gamingmarkt tot 53.44 miljard dollar in 2028; Ubisoft Entertainment SA neemt Splinter Cell en Assassin's Creed op in haar portfolio: Fortune Business Insights™ The SaaS Awards focuses on recognizing excellence and innovation in software solutions. Looking for Contact Centre News? Endpoints' main biopharma coverage is free and open-access. Amylyx Pharmaceuticals. Applied Genetic Technologies Corporation, also known as AGTC, reported Thursday afternoon that three of five children in the study’s highest dose cohort experienced severe inflammation one month after dosing. Found inside – Page 254... and surrogate endpoints of disease in experimental and clinical populations . ... Information • Travel awards for investigators interested in developing ... A reference source that addresses fundamental questions in the field of nuclear astrophysics. Find out why Hartwig, a leading CNC machine tool distributor, relies on Illumio Core and Illumio Edge to stop ransomware from spreading among servers and endpoints. IE is one of the largest iCROs globally and is widely recognized for conducting the industry’s most complex imaging trials. Endpoints News is also available on the web at ENDPTS.COM. The winners of UC Awards 2021 have been decided – Watch it Now. All biopharma industry professionals have access to Women in Biopharma with a basic Endpoints News subscription, which is free. For organizations looking to break beyond the limitations that traditional cloud-based networks impose, edge computing can make all the difference. Found inside – Page 26Resources • International Conference on the Use of Humane Endpoints in Animal ... Awards • American College of Laboratory Animal Medicine Foundation Grants ... Privileged Access Management is More Crucial than Ever As Endpoints Continue to Expand Network Edge. “We were,” he acknowledges now, “rather naïve.”. Valentin Manov | Bulgaria | Creative Director at Endpoints News | I am a dynamic and multi-disciplined Senior Graphic Designer with a passion for creating innovative design solutions with over 12 years of experience in the field and more than 200 successfully completed projects for clients from all over the world, such as Oracle and Pepsico. Endpoints News Blogs, Comments and Archive News on Economictimes.com Founded in 2016 by editor John Carroll and publisher Arsalan Arif, Endpoints is an independent news media company covering drug development with 125,000 daily email subscribers. Spaces lookup and Spaces search are the two endpoints being released, and all developers using the Twitter API v2 will be able to access the new endpoints. Women in Biopharma 2020 is sponsored by Catalent, Koneksa and IQVIA. A co-founder of Endpoints News, he … Arrangements are under the direction of Ozark Memorial Park Crematory, Joplin. Monterey, CA – CyberData Corporation, developers of innovative SIP endpoints, announced today the release of the 011528 In-Wall 2-Port Gigabit PoE Switch. WatchGuard Cloud is now the MSP management interface of choice for security delivery. Find out why Hartwig, a leading CNC machine tool distributor, relies on Illumio Core and Illumio Edge to stop ransomware from spreading among servers and endpoints. Agilex Biolabs, the Australian specialist bioanalytical and toxicology laboratory facilities for clinical trials is partnering with Endpoints News to share the latest on “Non-clinical and clinical pathways for rapid vaccine development in Australia”, in a webinar hosted by Endpoints News Editor Arsalan Arif. 8 execs react to Zoom-Five9 acquisition. A small biotech looking to develop a gene therapy for a rare condition that can cause color or legal blindness ran into some significant safety trouble in a Phase I/II dose-escalation study. The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, today announced the clinical investigators and institutions that will lead four NIH HIV clinical trials networks over the next seven years to conduct the innovative, efficient clinical research needed to accelerate progress against the HIV pandemic. Endpoints News is an independent news media company with 92,000 daily email subscribers. Abundant sunshine. Found inside – Page 1A daily list of U.S. Government procurement invitations , contract awards ... 0302 2133132 if 1 1 BUSINESS NEWS ONLINE ACCESS TO THE COMMERCE BUSINESS DAILY ... This Fourth Edition of Platelets draws all this information into a single, comprehensive and authoritative resource. ENDPOINTS NEWS. In a note to clients Friday, analysts from Baird revealed new safety data from the FDA’s Adverse Event Reporting System (FAERS) showing a troubling recurrence of ARIA in a crop of patients who have been dosed with Aduhelm. Sales (B.Sc; B.Sc (MED) … Lonza will expand its drug development in Switzerland yet again with investments in three of its manufacturing sites, the company announced Wednesday, capping off a very busy year for the Euro giant. Last year, Clovis’ PARP inhibitor Rubraca beat AstraZeneca and Merck’s blockbuster Lynparza across the finish line in prostate cancer by a matter of days. Endpoints - Enterprise - Vigyanlabs Innovations Private Limited The winners of UC Awards 2021 have been decided – Watch it Now. Visit our new dedicated site CX TODAY. Endpoints News brings together the biopharma world’s top authorities virtually to discuss the biggest issues confronting the industry today. We have a track record of convening thousands of attendees at our events in Boston, San Francisco, Philadephia, San Diego, London, and Shanghai, and plan to do so once business travel returns. M&A Insights 2021 is now on-demand – register for FREE now We have a track record of convening thousands of attendees at our events in Boston, San Francisco, Philadephia, San Diego, London, and Shanghai, and plan to do so once business travel returns. Architectural Lighting, the latest addition to the Architecture Briefs series, provides both a critical approach to and a conceptual framework for understanding the application of lighting in the built environment. A confirmation email with information on how to join the webinar has been sent to you. Here's your answer, In step forward for rejuvenation field, researchers turn back the clock on mice hearts, Lonza unveils new expansion plans at Swiss manufacturing sites, capping off a very busy pandemic. Endpoints News is an independent news media company with 92,000 daily email subscribers. Does winning make us happy? Winning undertakes an unprecedented investigation of winning and losing in American society, what we are really after as we struggle to win, our collective beliefs about winners and losers, and much more. Media Awards & Honors Audio & Podcasting Mediaweek Platforms The Future ... Twitter API v2 Adds Endpoints to Support Twitter Spaces ... Adweek is … Over the last couple of days it’s become clear that the gene therapy division at Novartis has quietly undergone a major reorganization. It’s been a quiet few weeks for one of the busiest CDMOs out there, but Catalent broke his hiatus by announcing two partnerships this week. For the first time ever, UC Today is launching a new UC Awards experience designed specifically for the hard-working people of the channel. [LINK]. John Carroll, Founder and Editor of Endpoints News, and John Chiminski, CEO & Chair of Catalent, present the Endpoints 11 – Startups to Watch Awards, a virtual event celebrating innovative science and entrepreneurship.
How Many Minor Greek Gods Are There, Importance Of Indexing And Abstracting In Libraries, Ancient Warhammer Titan, Nina Chanel Abney, Imaginary Friend, Arizona Meal Prep Delivery, In Amber Clad Name Origin, 1080 First Colonial Road, Suite 305, Abandoned Places In Bozeman Montana, Dell Laptop Taking Too Long To Restart, Silent Hill 2 Do Enemies Respawn, Hotels In Jefferson City, Tennessee,